Medical Inquiries and Observations is a four volume book internal medicine written by American physician and founder of Dickinson College, Dr. Benjamin Rush.

The histories of the yellow fever as epidemics, and of its sporadic cases, have been published in the order in which they have appeared in Philadelphia, to show the influence of the weather upon it, and the impropriety and danger of applying the same remedies for the same epidemic, in different and even successive seasons. The records of the first cases of yellow fever, which have appeared in each of the twelve years that have been noticed, are intended further to show the inefficacy of all the means, at present employed, to prevent its future recurrence.

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